Generic Name: chlophedianol, guaifenesin, and phenylephrine (KLOE fe DYE a nol, gwye FEN e sin, and FEN il EFF rin)
Brand Names: Donatussin
What is Donatussin (chlophedianol, guaifenesin, and phenylephrine)?
Chlophedianol is a cough suppressant. It affects the signals in the brain that trigger cough reflex.
Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.
Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
The combination of chlophedianol, guaifenesin, and phenylephrine is used to treat stuffy nose, cough, chest congestion, and sinus congestion caused by allergies, the common cold, or the flu.
Chlophedianol, guaifenesin, and phenylephrine will not treat a cough that is caused by smoking, asthma, or emphysema.
Chlophedianol, guaifenesin, and phenylephrine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Donatussin (chlophedianol, guaifenesin, and phenylephrine)?
Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as high blood pressure, heart disease, coronary artery disease, or a thyroid disorder. Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.
What should I discuss with my healthcare provider before taking Donatussin (chlophedianol, guaifenesin, and phenylephrine)?
Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as high blood pressure, heart disease, coronary artery disease, or a thyroid disorder.
To make sure you can safely use this medicine, tell your doctor if you have any of these other conditions:
diabetes;
epilepsy or other seizure disorder;
cough with mucus, or cough caused by emphysema, or chronic bronchitis;
enlarged prostate or urination problems; or
pheochromocytoma (an adrenal gland tumor).
It is not known whether chlophedianol, guaifenesin, and phenylephrine will harm an unborn baby. Do not use cough or cold medicine without telling your doctor if you are pregnant or plan to become pregnant while using the medicine. Chlophedianol, guaifenesin, and phenylephrine may pass into breast milk and may harm a nursing baby. Decongestants may also slow breast milk production. Do not use cough or cold medicine without telling your doctor if you are breast-feeding a baby.
How should I take Donatussin (chlophedianol, guaifenesin, and phenylephrine)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Cough or cold medicine is usually taken only for a short time until your symptoms clear up.
Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.
Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.
If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken a cough or cold medicine within the past few days. Store at room temperature away from moisture and heat. Do not freeze.
What happens if I miss a dose?
Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.
What should I avoid while taking Donatussin (chlophedianol, guaifenesin, and phenylephrine)?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlophedianol, guaifenesin, and phenylephrine. Ask a doctor or pharmacist before using any other cold, allergy, or cough medicine. Antitussives, expectorants, and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antitussive, expectorant, or decongestant.
Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.
Donatussin (chlophedianol, guaifenesin, and phenylephrine) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using chlophedianol, guaifenesin, and phenylephrine and call your doctor at once if you have a serious side effect such as:
fast, slow, or uneven heart rate;
severe dizziness or anxiety, feeling like you might pass out;
mood changes, hallucinations;
severe headache;
tremor, seizure (convulsions);
fever; or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, uneven heartbeats, seizure).
Less serious side effects may include:
mild dizziness or drowsiness;
mild headache;
diarrhea, constipation, nausea, upset stomach;
sleep problems (insomnia); or
feeling nervous or restless.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Donatussin (chlophedianol, guaifenesin, and phenylephrine)?
Before using chlophedianol, guaifenesin, and phenylephrine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlophedianol or guaifenesin.
There may be other drugs that can interact with chlophedianol, guaifenesin, and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
More Donatussin resources
- Donatussin Side Effects (in more detail)
- Donatussin Drug Interactions
- Donatussin Support Group
- 0 Reviews for Donatussin - Add your own review/rating
- Donatussin Liquid MedFacts Consumer Leaflet (Wolters Kluwer)
Compare Donatussin with other medications
- Cough and Nasal Congestion
Where can I get more information?
- Your pharmacist can provide more information about chlophedianol, guaifenesin, and phenylephrine.
See also: Donatussin side effects (in more detail)
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