Generic Name: brompheniramine and codeine (BROM fen IR a meen and KOE deen)
Brand Names: EndaCof-AC, Nalex AC
What is brompheniramine and codeine?
Brompheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Codeine is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.
The combination of brompheniramine and codeine is used to treat runny nose, sneezing, itching, watery eyes, and cough caused by allergies, the common cold, or the flu.
Brompheniramine and codeine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about brompheniramine and codeine?
You should not use this medication if you have severe liver disease, severe constipation, severe colitis or toxic megacolon, if you are unable to urinate, if you have been sick with diarrhea, if you recently drank large amounts of alcohol, or if you have a head injury or brain tumor. Do not use cough and cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, or overactive thyroid. Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.
What should I discuss with my healthcare provider before taking brompheniramine and codeine?
Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you have severe liver disease, severe constipation, severe colitis or toxic megacolon, if you are unable to urinate, if you have been sick with diarrhea, if you recently drank large amounts of alcohol, or if you have a head injury or brain tumor. Do not use cough and cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, or overactive thyroid.
To make sure you can safely take this medicine, tell your doctor if you have any of these other conditions:
a blockage in your digestive tract (stomach or intestines), a colostomy or ileostomy;
diabetes;
liver or kidney disease;
epilepsy or other seizure disorder;
enlarged prostate or urination problems;
an adrenal gland tumor or disorder (such as Addison's disease); or
if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).
Codeine may be habit forming and should be used only by the person it was prescribed for. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. FDA pregnancy category C. Codeine may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. Codeine can pass into breast milk and may harm a nursing baby. The use of codeine by some nursing mothers may lead to life-threatening side effects in the baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take brompheniramine and codeine?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.
Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.
Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken a cough or cold medicine within the past few days. Store at room temperature away from moisture and heat. Do not freeze. Keep track of the amount of medicine used from each new bottle. Codeine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
See also: Brompheniramine and codeine dosage (in more detail)
What happens if I miss a dose?
Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of codeine can be fatal.
Overdose symptoms may include confusion, extreme weakness, pinpoint pupils, cold and clammy skin, weak pulse, slow breathing, fainting, or breathing that stops. Overdose symptoms may also include severe forms of some of the side effects listed in this medication guide.
What should I avoid while taking brompheniramine and codeine?
Do not drink alcohol while you are taking medicine that contains codeine. Dangerous side effects or death can occur when alcohol is combined with a narcotic medicine. Check your food and medicine labels to be sure these products do not contain alcohol. Ask a doctor or pharmacist before using any other cold, cough, allergy, or sleep medicine. Antihistamines and cough suppressants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or cough suppressant. This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
Brompheniramine and codeine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking the medication and call your doctor at once if you have a serious side effect such as:
confusion, hallucinations, unusual thoughts or behavior;
severe dizziness or drowsiness;
urinating less than usual or not at all;
ringing in your ears; or
weak or shallow breathing.
Less serious side effects may include:
dizziness, drowsiness, problems with memory or concentration;
dry mouth, nose, or throat, increased sweating or urination;
mild stomach pain, diarrhea or constipation;
blurred vision; or
flushing (warmth, redness, or tingly feeling).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Brompheniramine and codeine Dosing Information
Usual Adult Dose for Cold Symptoms:
5 mL to 10 mL orally every 4 to 6 hours. Not to exceed 30 mL in 24 hours.
Usual Pediatric Dose for Cold Symptoms:
6 years to 11 years: 5 mL orally every 4 to 6 hours. Not to exceed 15 mL in 24 hours.
12 years or older: 5 mL to 10 mL orally every 4 to 6 hours. Not to exceed 30 mL in 24 hours.
What other drugs will affect brompheniramine and codeine?
Before using this medicine, tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicines, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by brompheniramine or codeine.
Tell your doctor about all other medications you use, especially:
alvimopan (Entereg);
atropine (Atreza, Sal-Tropine);
benztropine (Cogentin);
cimetidine (Tagamet);
naloxone (Narcan, Suboxone), naltrexone (ReVia);
topiramate (Topamax);
tramadol (Ultram, Ultracet);
zonisamide (Zonegran);
an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), bupropion (Wellbutrin), doxepin (Sinequan, Silenor), nortriptyline (Pamelor), and others;
anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), droperidol (Inapsine), methscopolamine (Pamine), or scopolamine (Transderm Scop);
bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;
bowel cleansing preparations (Half Lytely, Fleet Prep Kit, Evac-Q-Kwik, GoLytely, Supraprep, and others);
bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);
heart or blood pressure medicine such as atenolol (Tenormin, Tenoretic), metoprolol (Dutoprol, Lopressor, Toprol), propranolol (Inderal, InnoPran), quinidine (Quin-G), and others;
irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or
ulcer medicine such as glycopyrrolate (Robinul) or mepenzolate (Cantil).
This list is not complete and other drugs may interact with brompheniramine and codeine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More brompheniramine and codeine resources
- Brompheniramine and codeine Side Effects (in more detail)
- Brompheniramine and codeine Dosage
- Brompheniramine and codeine Use in Pregnancy & Breastfeeding
- Brompheniramine and codeine Drug Interactions
- Brompheniramine and codeine Support Group
- 0 Reviews for Brompheniramine and codeine - Add your own review/rating
Compare brompheniramine and codeine with other medications
- Cold Symptoms
- Cough
- Rhinorrhea
Where can I get more information?
- Your pharmacist can provide more information about brompheniramine and codeine.
See also: brompheniramine and codeine side effects (in more detail)
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